Optimizing the Spatio-Temporal Analysis of Imaging Data

Research Plan (color figures)

A postscript copy of the research plan for my K25 grant proposal. This copy has color figures.

Movies:

Comparison of Mouse Heart Data: Cleaned vs. Raw

A movie comparing a cleaned data set of the action potential in mouse heart with a raw data set. The pixels have been mean-subtracted, and normalized to their standard deviation in order to make the improvement in signal-to-noise ratio clear.

Reconstructed fMRI Data

The reconstructed timecourse of the BOLD response detected using functional Magnetic Resonance Imaging (fMRI) to a finger-tapping experiment. This response is actually from toe-tapping. Note the obvious signature of the vasculature.

Timecourse of the Orientation Response in Cat V1

The difference of two movies, one taken of the response in cat primary visual cortex to a horizontal drifting grating, and the other of the response to a vertical drifting grating. Note the emergence of a dappled pattern due to the difference in neuronal populations responding to different orientations.

Waves in Macaque V1

A movie of the dominant component of the response to drifting grating stimulus in macaque cortex: spatiotemporal waves. Two principal components containing this response were naturally separated by a principal component analysis (PCA) of a cleaned reconstruction of the imaging data using our method.

Ocular Dominance Response in Macaque V1

A movie of the ocular dominance response in macaque visual cortex. This component also separated naturally in one principal component (actually with a small amount of power in a second component, which is included in the movie).